La Red Centinela Sanitaria de Castilla y León promueve la publicación, propia y en colaboración, de estudios basados en la información extraída de los diferentes programas de registro. En esta página se recogen los artículos científicos más destacados.

2025

  • Puerto AM, Lozano JE, Lozano M, Basile L, Naveira-Barbeito G, Guiu Cañete I, Linares Dópido JA, Fernández Ibáñez A, Ibáñez Pérez AC, Castrillejo D, Rivas Wagner E, Valcárcel de la Iglesia MÁ, Pérez Morilla E, Martínez-Pino I, Vega T, Monge S; SiVIRA‐MEM collaborators. Establishing Epidemic and Intensity Thresholds After a Major Change in Respiratory Virus Surveillance in Spain in 2020. Influenza Other Respir Viruses. 2025 Sep;19(9):e70136. doi: 10.1111/irv.70136. PMID: 40983959; PMCID: PMC12453968

2024

  • Pérez-Gimeno Gloria, Mazagatos Clara, Lorusso Nicola, Basile Luca, Martínez-Pino Isabel, Corpas Burgos Francisca, Batalla Rebolla Noa, Rumayor Zarzuelo Mercedes B, Andreu Ivorra Blanca, Giménez Duran Jaume, Castrillejo Daniel, Guiu Cañete Inés, Huerta Huerta Marta, García Becerril Marta, Ramos Marín Violeta, Casas Inmaculada, Pozo Francisco, Monge Susana, the SiVIRA group. Effectiveness of influenza vaccines in children aged 6 to 59months: a testnegative case–control study at primary care and hospital level, Spain 2023/24. Euro Surveill. 2024;29(40):pii=2400618. https://doi.org/10.2807/1560-7917. ES.2024.29.40.2400618Este enlace se abrirá en una ventana nueva. PMID: 39364601. PMCID: PMC11451132Este enlace se abrirá en una ventana nueva
  • Vega-alonso, T., Lozano-alonso, J., Estévez-iglesias, L., Ordax-díez, A., Arrieta-antón, E., Pita, G., Pinto-labajo, R., Ramos, M. A., & Álamo-sanz, R. (2024). Health and wellbeing status of the long-lived individuals of the Spanish LONGECYL cross- sectional study. 5, 1–13.
  • Laniece Delaunay C, Mazagatos C, Martínez-Baz I, Túri G, Goerlitz L, Domegan L, Meijer A, Rodrigues AP, Sève N, Ilic M, Latorre-Margalef N, Lazar M, Maurel M, Melo A, Andreu Ivorra B, Casado I, Horváth JK, Buda S, Bennett C, de Lange M, Guiomar R, Enouf V, Mlinaric I, Samuelsson Hagey T, Dinu S, Rumayor M, Castilla J, Oroszi B, Dürrwald R, O'Donnell J, Hooiveld M, Gomez V, Falchi A, Kurecic Filipovic S, Dillner L, Popescu R, Bacci S, Kaczmarek M, Kissling E; VEBIS Primary Care Vaccine Effectiveness Group. COVID-19 Vaccine Effectiveness in Autumn and Winter 2022 to 2023 Among Older Europeans. JAMA Netw Open. 2024 Jul 1;7(7):e2419258. doi: 10.1001/jamanetworkopen.2024.19258. PMID: 38949812; PMCID: PMC11217869.
  • García-Azorín D, Santana-López L, Lozano-Alonso JE, Ordax-Díez A, Vega-Alonso T, Macias Saint-Gerons D, González-Osorio Y, Rojo-Rello S, Eiros JM, Sánchez-Martínez J, Sierra-Mencía Á, Recio-García A, Martín-Toribio A, Sanz-Muñoz I, Guerrero-Peral ÁL. Factors associated to the presence of headache in patients with influenza infection and its consequences: a 2010-2020 surveillance-based study. J Headache Pain. 2024 Feb 8;25(1):18. doi: 10.1186/s10194-024-01728-z. PMID: 38331709; PMCID: PMC10854039.
  • NCD Risk Factor Collaboration (NCD-RisC). Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults. Lancet. 2024 Mar 16;403(10431):1027-1050. doi: 10.1016/S0140-6736(23)02750-2. Epub 2024 Feb 29. PMID: 38432237; PMCID: PMC7615769.
  • NCD Risk Factor Collaboration (NCD-RisC). Worldwide trends in diabetes prevalence and treatment from 1990 to 2022: a pooled analysis of 1108 population-representative studies with 141 million participants. Lancet. 2024 Nov 23;404(10467):2077-2093. doi: 10.1016/S0140-6736(24)02317-1. Epub 2024 Nov 13. Erratum in: Lancet. 2025 Apr 5;405(10485):1146. doi: 10.1016/S0140-6736(25)00620-8. PMID: 39549716; PMCID: PMC7616842.
  • NCD Risk Factor Collaboration (NCD-RisC). General and abdominal adiposity and hypertension in eight world regions: a pooled analysis of 837 population-based studies with 7·5 million participants. Lancet. 2024 Aug 31;404(10455):851-863. doi: 10.1016/S0140-6736(24)01405-3. PMID: 39216975; PMCID: PMC7616775.

2023

  • Vega-Alonso Tomás, Lozano-Alonso Jose Eugenio, Ordax-Díez Ana, on behalf of the VIGIRA Research Group. Comprehensive surveillance of acute respiratory infections during the COVID-19 pandemic: a methodological approach using sentinel networks, Castilla y León, Spain, January 2020 to May 2022. Euro Surveill. 2023;28(21):pii=2200638. https://doi.org/10.2807/1560-7917.ES.2023.28.21.2200638
  • Phelps, N. H., Singleton, R. K., & Zhou, B. (2023). Worldwide trends in the burden of underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million school-aged children, adolescents and adults. The Lancet, 6736(23), 1–24. https://doi.org/10.1016/S0140-6736(23)02750-2Este enlace se abrirá en una ventana nueva
  • Onieva, A., Martin, J., Cuesta-Aguirre, D. R., Planells, V., Coronado-Zamora, M., Beyer, K., Vega, T., Eugenio Lozano, J., Santos, C., &Pilar Aluja, M. (2023). Complete mitochondrial DNA profile in stroke: a geographical matched case-control study in Spanish population. Mitochondrion. https://doi.org/10.1016/J.MITO.2023.10.001Este enlace se abrirá en una ventana nueva
  • Kissling E, Maurel M, Emborg HD, Whitaker H, McMenamin J, Howard J, Trebbien R, Watson C, Findlay B, Pozo F, Bolt Botnen A, Harvey C, Rose A; European IVE group; Members of the European IVE group. Interim 2022/23 influenza vaccine effectiveness: six European studies, October 2022 to January 2023. Euro Surveill. 2023 May;28(21):2300116. doi: 10.2807/1560-7917.ES.2023.28.21.2300116. PMID: 37227299; PMCID: PMC10283457.
  • Pairo-Castineira E, Rawlik K, Bretherick AD, Qi T, Wu Y, Nassiri I, McConkey GA, Zechner M, Klaric L, Griffiths F, Oosthuyzen W, Kousathanas A, Richmond A, Millar J, Russell CD, Malinauskas T, Thwaites R, Morrice K, Keating S, Maslove D, Nichol A, Semple MG, Knight J, Shankar-Hari M, Summers C, Hinds C, Horby P, Ling L, McAuley D, Montgomery H, Openshaw PJM, Begg C, Walsh T, Tenesa A, Flores C, Riancho JA, Rojas-Martinez A, Lapunzina P; GenOMICC Investigators; SCOURGE Consortium; ISARICC Investigators; 23andMe COVID-19 Team; Yang J, Ponting CP, Wilson JF, Vitart V, Abedalthagafi M, Luchessi AD, Parra EJ, Cruz R, Carracedo A, Fawkes A, Murphy L, Rowan K, Pereira AC, Law A, Fairfax B, Hendry SC, Baillie JK. GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19. Nature. 2023 May;617(7962):764-768. doi: 10.1038/s41586-023-06034-3. Epub 2023 May 17. Erratum in: Nature. 2023 Jul;619(7971):E61. doi: 10.1038/s41586-023-06383-z. PMID: 37198478; PMCID: PMC10208981.

2022

  • Vega, T., Hilario, F., Pérez-Caro, M., Núñez-Torres, R., Pinto, R. M., & González-Neira, A. (2022). Genetic, environmental and life-style factors associated with longevity. Protocol and response of the LONGECYL Study. Gaceta Sanitaria, 36(3), 260–264. https://doi.org/10.1016/j.gaceta.2022.01.005Este enlace se abrirá en una ventana nueva
  • Guerrisi, C., Thomas, B., Ordax Diez, A., Van Cauteren, D., Lozano Alonso, J. E., Moreels, S., Falchi, A., Vega Alonso, T., Bonmarin, I., Raude, J., Vilcu, A. M., Hanslik, T., Debin, M., Rossignol, L., Colizza, V., Souty, C., & Blanchon, T. (2022). Initial risk perception and feeling of preparedness of primary care physicians regarding the COVID-19 pandemic in Belgium, France and Spain in February 2020. BMC Primary Care, 23(1), 1–8. https://doi.org/10.1186/s12875-021-01588-5Este enlace se abrirá en una ventana nueva
  • Verkissen MN, Penders YWH, Onwuteaka-Philipsen BD, Moreels S, Donker GA, Vega Alonso T, Van den Block L, Deliens L. End-of-life communication in advanced cancer: international trends (2009-2014). BMJ Support Palliat Care. 2022 Jul;12(e2):e236-e247. doi: 10.1136/bmjspcare-2019-001999. Epub 2020 Apr 27. PMID: 32341055.

2021

  • López-Ortiz, S., Valenzuela, P. L., Seisdedos, M. M., Morales, J. S., Vega, T., Castillo-García, A., Nisticò, R., Mercuri, N. B., Lista, S., Lucia, A., & Santos-Lozano, A. (2021). Exercise interventions in Alzheimer’s disease: A systematic review and meta-analysis of randomized controlled trials. Ageing Research Reviews, 72(March). https://doi.org/10.1016/j.arr.2021.101479
  • Risk, N. C. D., & Collaboration, F. (2021). Heterogeneous contributions of change in population distribution of body mass index to change in obesity and underweight. 1–35.
  • NCD Risk Factor Collaboration (NCD-RisC). Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants. Lancet. 2021 Sep 11;398(10304):957-980. doi: 10.1016/S0140-6736(21)01330-1. Epub 2021 Aug 24. Erratum in: Lancet. 2022 Feb 5;399(10324):520. doi: 10.1016/S0140-6736(22)00061-7. PMID: 34450083; PMCID: PMC8446938.
  • NCD Risk Factor Collaboration (NCD-RisC). Heterogeneous contributions of change in population distribution of body mass index to change in obesity and underweight. Elife. 2021 Mar 9;10:e60060. doi: 10.7554/eLife.60060. PMID: 33685583; PMCID: PMC7943191.

2020

  • Redondo-bravo, L., Delgado-sanz, C., Oliva, J., Vega, T., Lozano, J., & Larrauri, A. (2020). Transmissibility of influenza during the 21st-century epidemics , Spain , influenza seasons 2001 / 02 to 2017 / 18. Ili, 1–10.
  • Basma AbdElGawad, Tomás Vega, Moustafa El Houssinie, Amira Mohsen, Manal Fahim, Hanaa Abu ElSood, Jean Jabbour, Alaa Eidy Samir Refaey. Evaluating tools to define influenza baseline and threshold values using surveillance data, Egypt, season 2016/17, http://doi.org/10.1016/j.jiph.2019.05.005Este enlace se abrirá en una ventana nueva

  • de Nooijer K, Pivodic L, Deliens L, Miccinesi G, Vega Alonso T, Moreels S, Van den Block L. Primary palliative care for older people in three European countries: a mortality follow-back quality study. BMJ Support Palliat Care. 2020 Dec;10(4):462-468. doi: 10.1136/bmjspcare-2019-001967. Epub 2019 Oct 16. PMID: 31619438; PMCID: PMC7691801.
  • NCD Risk Factor Collaboration (NCD-RisC). Height and body-mass index trajectories of school-aged children and adolescents from 1985 to 2019 in 200 countries and territories: a pooled analysis of 2181 population-based studies with 65 million participants. Lancet. 2020 Nov 7;396(10261):1511-1524. doi: 10.1016/S0140-6736(20)31859-6. PMID: 33160572; PMCID: PMC7658740.

2019

  • Umbria, M., Ramos, A., Caner, J., Vega, T., Lozano, J. E., Santos, C., & Aluja, M. P. (2019). Involvement of mitochondrial haplogroups in myocardial infarction and stroke: A case-control study in Castile and Leon (Spain) population. Mitochondrion, 44. https://doi.org/10.1016/j.mito.2017.12.004
  • Nooijer K, Pivodic L, Deliens L, Miccinesi G, Vega Alonso T, Moreels S and Van den Block L. Primary palliative care for older people in three European countries: a mortality follow-back quality study. http://dx.doi.org/10.1136/bmjspcare-2019-001967Este enlace se abrirá en una ventana nueva

2018

  • Broberg, E. K. E. K., Waris, M., Johansen, K., Snacken, R., Penttinen, P., Network, E. I. S., Trebbien, R., Emborg, H.-D., Krause, T. G., Fischer, T. K., Kuznetsova, N., Dotsenko, L., Sadikova, O., Behillil, S., Blanchon, T., Capai, L., Cohen, J.-M., Enouf, V., Falchi, A., … McMenamin, J. (2018). Seasonality and geographical spread of respiratory syncytial virus epidemics in 15 European countries, 2010 to 2016. Eurosurveillance, 23(5), 17–00284. https://doi.org/10.2807/1560-7917.es.2018.23.5.17-00284

2017

  • Bangert M, Gil H, Oliva J, Delgado C, Vega T, DE Mateo S, Larrauri A; Epidemiology Working Group of the Spanish Influenza Sentinel Surveillance System. Pilot study to harmonize the reported influenza intensity levels within the Spanish Influenza Sentinel Surveillance System (SISSS) using the Moving Epidemic Method (MEM). Epidemiol Infect. 2017;145(4):715-722. doi: 10.1017/S0950268816002727Este enlace se abrirá en una ventana nueva
  • NCD Risk Factor Collaboration (NCD-RisC). Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128·9 million children, adolescents, and adults. Lancet. 2017 Dec 16;390(10113):2627-2642. doi: 10.1016/S0140-6736(17)32129-3. Epub 2017 Oct 10. PMID: 29029897; PMCID: PMC5735219.
  • NCD Risk Factor Collaboration (NCD-RisC). Worldwide trends in blood pressure from 1975 to 2015: a pooled analysis of 1479 population-based measurement studies with 19·1 million participants. Lancet. 2017 Jan 7;389(10064):37-55. doi: 10.1016/S0140-6736(16)31919-5. Epub 2016 Nov 16. Erratum in: Lancet. 2020 Sep 26;396(10255):886. doi: 10.1016/S0140-6736(20)31972-3. PMID: 27863813; PMCID: PMC5220163.

2016

  • Pivodic L, Pardon K, Miccinesi G, Vega Alonso T, Moreels S, Donker GA, Arrieta E, Onwuteaka-Philipsen BD, Deliens L, Van den Block L. Hospitalisations at the end of life in four European countries: a population-based study via epidemiological surveillance networks. J Epidemiol Community Health 2016;70:430-436Este enlace se abrirá en una ventana nueva. doi: 10.1136/jech-2015-206073.

  • Vega Alonso T, Miralles Espí M, Mangas Reina JM, Castrillejo Pérez D, Rivas Pérez AI, Gil Costa M, López Maside A, Arrieta Antón E, Lozano Alonso JE, Fragua Gil M. Prevalencia de deterioro cognitivo en España. Estudio Gómez de Caso en redes centinelas sanitarias. Neurologia. 2016: S0213-4853(16)30217-1. Disponible en:
    http://www.sciencedirect.com/science/article/pii/S0213485316302171Este enlace se abrirá en una ventana nueva

  • Gherasim A, Pozo F, de Mateo S, Gamarra IA, García-Cenoz M, Vega T, Martínez E, Giménez J, Castrillejo D, Larrauri A; cycEVA team and the VEVA Working Group. Waning protection of influenza vaccine against mild laboratory confirmed influenza A(H3N2) and B in Spain, season 2014-15. Vaccine. 2016;34(20):2371-7. Disponible en:
    http://www.sciencedirect.com/science/article/pii/S0264410X16300081Este enlace se abrirá en una ventana nueva

  • NCD Risk Factor Collaboration (NCD-RisC). Worldwide trends in diabetes since 1980: a pooled analysis of 751 population-based studies with 4.4 million participants. Lancet. 2016 Apr 9;387(10027):1513-1530. doi: 10.1016/S0140-6736(16)00618-8. Epub 2016 Apr 6. Erratum in: Lancet. 2017 Feb 4;389(10068):e2. doi: 10.1016/S0140-6736(16)32060-8. PMID: 27061677; PMCID: PMC5081106.

2015



  • Van den Block L, Pivodic L, Pardon K, Donker G, Miccinesi G, Moreels S, Vega Alonso T, Deliens L, Onwuteaka-Philipsen B. Transitions between health care settings in the final three months of life in four EU countries. Eur J Public Health. 2015 Aug;25(4):569-75. doi: https://doi.org/10.1093/eurpub/ckv039Este enlace se abrirá en una ventana nueva.



  • Arrieta E, Gómez de Caso (†) JÁ, Vega T, Lozano JE, Zuriaga O. Pacientes que reciben atención sanitaria paliativa y de soporte de los equipos de atención primaria en el domicilio. Estudio APASO, mediante Redes Centinelas Sanitarias. Med Paliativa [Internet]. 2015 May [citado 2015 Sep 16];40(14):1–2. Disponible en: http://linkinghub.elsevier.com/retrieve/pii/S1134248X14001104Este enlace se abrirá en una ventana nueva

2014



2013

  • Vega, T., Lozano, J. E., Meerhoff, T., Snacken, R., Mott, J., Ortiz de Lejarazu, R., & Nunes, B. (2013). Influenza surveillance in Europe: establishing epidemic thresholds by the moving epidemic method. Influenza and Other Respiratory Viruses, 7(4), 546–558. https://doi.org/10.1111/j.1750-2659.2012.00422.xEste enlace se abrirá en una ventana nueva

2011-2012


2002-2009

  • Bermejo-Martin JF, Tenorio-Abreu A, Vega T, Eiros JM, Castrodeza J, de Lejarazu RO. Prepandemic influenza vaccines. Lancet Infect Dis. 2009 Apr;9(4):206-7; author reply 207-9. doi: 10.1016/S1473-3099(09)70067-2. PMID: 19324290.
  • Vega T, Zurriaga O, Ramos JM, Gil M, Alamo R, Lozano JE, López A, Miralles MT, Vaca P, Alvarez M; Group of research for the RECENT project. Stroke in Spain: epidemiologic incidence and patterns. A health sentinel network study.J Stroke Cerebrovasc Dis. 2009;18:11-16.





1990-1999


  • Vega Alonso T, Ramírez Fernández R, Larranaga Padilla M, Urbina Torija J, Zurriaga Llorens O, González Santa Cruz L. La coordinación de las redes centinelas y las nuevas etapas de la vigilancia epidemiológica. Gac Sanit. 1998; 12:190-1



Basma AbdElGawadEste enlace se abrirá en una ventana nueva, Tomás VegaEste enlace se abrirá en una ventana nueva, Moustafa El HoussinieEste enlace se abrirá en una ventana nueva, Amira MohsenEste enlace se abrirá en una ventana nueva, Manal FahimEste enlace se abrirá en una ventana nueva, Hanaa Abu ElSoodEste enlace se abrirá en una ventana nueva, Jean JabbourEste enlace se abrirá en una ventana nueva, Alaa EidEste enlace se abrirá en una ventana nuevay Samir RefaeyEste enlace se abrirá en una ventana nueva. Evaluating tools to define influenza baseline and threshold values using surveillance data, Egypt, season 2016/17, http://doi.org/10.1016/j.jiph.2019.05.005